The Chillicothe Post of the Ohio State Highway Patrol reported it on Buchanan Road at about 9:15am.
A 1995 Ford F-150 driven by 18-year-old Alexander McDowell of Piketon was struck head-on by a 2003 Isuzu Rodeo driven by 33-year-old Jeremy Mallow of Waverly.
Passengers in McDowell’s vehicle were 25-year-old Joshua Taylor of Piketon, and 15-year-old Christopher Chaney and 15-year-old Clayton Ison of Waverly.
Mallow was flown from the scene by Medflight to Cable-Huntington Hospital. Taylor was flown by AirEvac to Ohio State University Wexner Hospital.
The crash was still under investigation and conditions were unknown at the time of the news release.