Two people are dead following a head-on crash on US 22 Wednesday evening in Fairfield County. A car driven by 49-year-old Patrick Anderson of Amanda was headed westbound on US 22 when it was struck head-on by a vehicle coming eastbound and driven by 47-year-old Michael Triplett of Johnstown. Triplett had crossed over the over double-yellow line. Anderson was pronounced dead at the scene. Michael Triplett suffered minor injuries. There were three other people in Triplett's car, one of those, 78-year-old Barbara Triplett, was riding in the front seat. She was transported to a Lancaster hospital where she later died as result of her injuries. The other two passengers remain hospitalized. The crash remains under investigation.